What Is a Cheaper Alternative to Ozempic?

Written by: Jillian Kubala, MS, RD
Medically reviewed by: Nesochi Okeke-Igbokwe, MD, MS

Ozempic can be a powerful tool for weight management and diabetes care, but it isn’t the only option out there. Between prescription alternatives, supplements that have evidence-based benefits for metabolic health and tried-and-true lifestyle changes like dietary tweaks and increasing physical activity, you have many ways to support your health goals. The most effective approach is often a combination of two or more of the above that feels sustainable for you. 

Ozempic has quickly become one of the most talked-about options for weight loss and managing symptoms of medical conditions like type 2 diabetes. 

But while its popularity has soared, the high price tag and limited insurance coverage have left many people searching for cheaper alternatives to Ozempic. 

In this article, we’ll explore more affordable prescription-based and natural alternatives to Ozempic that can help support your health goals, including weight loss.  

WHY LOOK FOR OZEMPIC ALTERNATIVES?

Ozempic is a prescription injectable medication that’s FDA-approved for managing type 2 diabetes. While Ozempic isn’t specifically prescribed or FDA-approved for losing weight, research shows it can promote significant weight loss, which is why it’s become increasingly popular among people looking to shed pounds.

While Ozempic does have benefits, it’s not the right choice for everyone. Here are some of the most common reasons why people seek out alternatives to Ozempic.

1. High cost and limited insurance coverage

If you’re prescribed Ozempic to help manage diabetes, many insurance will typically cover the cost. However, if you don’t have diabetes and get a prescription for a medication like Ozempic for weight loss, insurance coverage can be limited. Often, Ozempic isn’t covered at all. 

Without insurance, Ozempic comes with a steep list price: $499 for a 30-day supply. This is following a recent 50% price cut—earlier in 2025, a 30-day supply was nearly $1,000.

2. Supply shortages

Skyrocketing demand for GLP-1 medications has caused periodic nationwide shortages, making it challenging to consistently fill Ozempic prescriptions. This supply issue can interrupt weight loss progress, not to mention cause a lot of stress for Ozempic users. 

3. Side effects

Like all medications, Ozempic can cause unpleasant side effects. The most common side effects Ozempic users face are gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation. While many people tolerate these symptoms well, some find them difficult to manage and disruptive to daily life. Also, Novo Nordisk, the pharmaceutical company that makes Ozempic, is currently facing lawsuits filed by patients who claim the drug caused serious side effects, raising concerns about its long-term safety. 

4. Preference for non-prescription solutions

Given Ozempic’s cost and potential side effects, many people are instead turning to over-the-counter supplements and lifestyle changes for weight management. Increased exercise, stress management practices, and certain supplements can help support weight loss and related health goals, such as improving blood sugar control and cholesterol levels. 

5. Medical conditions

Ozempic isn’t recommended for people with a history of the following: 

• Thyroid tumors

• Medullary thyroid carcinoma (MTC), or a family history of MTC

• Multiple Endocrine Neoplasia type 2 (MEN 2)

• Diabetic retinopathy

• Certain kidney and pancreatic conditions

You can visit the FDA website for the full list of contraindications and precautions.

6. Fear of needles

Ozempic is an injectable medication and therefore not a fit for those with a significant fear of needles.

PRESCRIPTION ALTERNATIVES TO OZEMPIC

The active ingredient in Ozempic is semaglutide, which is classified as a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 agonists work by activating receptors for GLP-1, a hormone that regulates blood sugar levels and appetite. (Wegovy and Rybelsus are two other common semaglutide-based GLP-1 medications.)

Unlike Ozempic, certain GLP-1 medications are approved for weight loss. With the former’s recent price adjustment, the following come with a higher price tag, at least for now. 

Trulicity (dulaglutide)

• Form: Injectable GLP-1

• Uses: FDA-approved for managing type 2 diabetes; prescribed off-label for weight loss.

• Active ingredient: Dulaglutide, a biologic medication

• How it works: Reduces appetite and slows gastric emptying.

• List price per month: $987.19*
  
  

Victoza (liraglutide)

• Form: Injectable GLP-1

• Uses: FDA-approved to improve glycemic control in adults and children over 10 with type 2 diabetes and reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular diseases. 

• Active ingredient: Liraglutide

• How it works: Reduces appetite and slows gastric emptying.

• List price per month: $543.51-$815.27*
  
  

Saxenda (liraglutide)

• Form: Injectable GLP-1

• Uses: FDA-approved for chronic weight management in adults with overweight or obesity and in children over 12 with obesity and reducing the risk of major cardiovascular events.

• Active ingredient: Liraglutide

• How it works: Reduces appetite and slows gastric emptying.

• List price per month: $1,349.02*
  
  

Zepbound (tirzepatide)

• Form: Injectable GLP-1 + GIP receptor agonist

• Uses: FDA-approved for weight loss in adults with obesity or overweight plus a weight-related health condition and to treat moderate to severe obstructive sleep apnea in adults with obesity. 

• Active ingredient: Tirzepatide

• How it works: Activates both GLP-1 and GIP receptors, which regulate appetite and may lead to greater weight loss as compared to semaglutide drugs like Ozempic.

• List price per month: $1,086.37* 
  
  

“NATURE'S OZEMPIC”: NATURAL ALTERNATIVES AND SUPPLEMENTS

Even if some prescription Ozempic alternatives are covered by insurance, they’re still not always available or easy to get for everyone who’d like to lose weight. Others are looking for non-prescription options to support their weight loss journey.

That’s where “GLP-1 supplements,” as they’re sometimes referred to, come in. If you’ve scrolled through health or wellness content on social media lately, chances are you’ve seen berberine and other plant-based ingredients dubbed “nature’s Ozempic.” The nickname might sound catchy (and a little oversimplified), but there’s some truth behind the buzz. 

“The term refers to natural compounds that mimic some of the appetite-suppressing and metabolism-supporting effects of GLP-1 receptor agonist medications such as Ozempic,” explains Dr. Lana Butner, board-certified naturopathic doctor (ND) and licensed acupuncturist (LAc). “These natural agents do not act as pharmaceutical GLP-1 drugs, but may support similar metabolic pathways, helping regulate appetite, blood sugar, and weight,” says Butner.

In other words, these supplements are not a direct replacement for prescription weight loss medications like Ozempic, but they can help support your body’s natural GLP-1 production. They’re also cheaper, easier to access, and typically have fewer side effects. 

Veracity’s natural alternative to GLP-1 medications, Metabolism Ignite, is a 100% plant-based supplement made with ingredients that have been clinically shown to safely support long-term weight management.

• Metabolaid: A blend of polyphenols sourced from lemon verbena and hibiscus extracts that supports weight management and appetite control by activating the AMP-activated protein kinase (AMPK) signaling pathway. This in turn helps reduce weight gain and manage obesity.

• Magnesium: This essential mineral is tied to many functions throughout the body, including regulating blood pressure and blood sugar. It also plays a vital role in improving both sleep quality and gut health. In fact, adequate magnesium intake is associated with a lower risk of inflammation and may contribute to improved gut health by supporting the growth of beneficial gut bacteria.

• Green coffee bean extract (caffeine-free): This popular supplement is made from raw coffee seeds and rich in chlorogenic acid. The available human clinical trials have indicated that it may be effective in promoting weight loss in people with overweight and obesity.

In a 2020 clinical trial, 84 adults with overweight or obesity were split into two groups—one took Metabolaid daily for 12 weeks, the other got a placebo. Without making any changes to their diet, the Metabolaid group lost significantly more weight, lowered their BMI, and reduced belly fat compared to the placebo group, suggesting that Metabolaid may help support healthy fat loss naturally.

Other studies show that Metabolaid can help lower blood pressure, decrease cholesterol, and boost the abundance of beneficial bacteria in your gut. A 2018 study found that Metabolaid improved meal satisfaction by 50% and reduced hunger by a whopping 85% after 60 days of use. 

METABOLISM IGNITE

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Here are some other common ingredients and supplements people use for weight management.

• Berberine: Berberine is a naturally occurring compound found in certain flowering plants that’s also available as a dietary supplement. Research suggests it may help lower fasting and post-meal blood sugar levels, as well as the long-term blood sugar control marker hemoglobin A1c (HbA1c), by improving insulin sensitivity and supporting more efficient glucose metabolism. It may also aid weight loss by reducing fat storage, improving insulin sensitivity, activating AMPK, and positively influencing gut microbiota.

• Chromium picolinate: This highly absorbable form of the mineral chromium that may help curb appetite by influencing neurotransmitters involved in mood regulation and eating behavior. Research suggests that supplementing with ≤400 micrograms of chromium picolinate per day for ≤12 weeks could lead to significant improvements in weight loss and body fat percentage.

• Fiber supplements: Studies show that fiber supplements, like glucomannan, inulin, and psyllium, may support weight loss and improve body composition. They work by decreasing hunger, increasing satiety, and slowing digestion.

• Green tea extract: Studies show that supplementing with green tea extract (which contains caffeine and catechins, including epigallocatechin gallate or EGCG), may help reduce body mass and body fat percentage. Additionally, it can also reduce markers of oxidative stress, which promotes overall health. 

• Conjugated linoleic acid (CLA): CLA is a type of polyunsaturated fatty acid naturally present in foods like dairy products and beef. It’s also available in concentrated form as a popular weight-loss supplement. Though more research is needed, some animal and human studies suggest that CLA may favorably modify body composition by stimulating the breakdown of body fat and increasing muscle mass.

• Garcinia cambogia: Made from the extract of the garcinia gummi-gutta fruit peel, garcinia cambogia’s active compound, hydroxycitric acid (HCA), is believed to help reduce appetite by increasing levels of the neurotransmitter serotonin. Some studies suggest it may help inhibit fat production, curb hunger, and promote modest weight loss in humans, but more research is needed to confirm its potential benefits. 

Remember that while these supplements can offer a natural alternative to GLP-1 medications, they may not be suitable for everyone. Always consult your doctor before adding a new supplement to your routine to ensure it's right for you. 

LIFESTYLE-BASED ALTERNATIVES TO OZEMPIC

The most important factors in weight management and metabolic health are following a nutrient-dense diet and leading a healthy lifestyle. Lifestyle changes, such as focusing on healthy eating or increasing physical activity, can be a highly effective alternative to medications like Ozempic. 

Diet

Though there’s no one approach that works for everyone, a well-rounded, nutrient-dense eating pattern that focuses on fiber and protein-rich foods is best for overall health, disease prevention, and weight loss. Studies show that healthy eating patterns, including low-carb, high-protein, and Mediterranean-style diets, can help regulate blood sugar, support satiety, and promote gradual, maintainable weight loss. 

Exercise 

Pairing a healthy diet with regular physical activity can help improve metabolism, increase and preserve lean muscle mass, and support weight loss and weight maintenance. What’s more, exercise, including resistance training, can significantly reduce the risk of metabolic disease. The CDC recommends that adults aim for 150 minutes of moderate-intensity activity, 75 minutes of vigorous-intensity activity, or a combination of both each week. The CDC also recommends strength training at least twice weekly to support muscle health and overall fitness.

Stress management 

Stress can significantly impact metabolic health and may impact your weight. Research shows that people who are stressed often consume more calories, particularly from foods high in ingredients like salt and sugar, which can lead to weight gain and other health issues. 

Stress may also disrupt hormone balance, leading to insulin resistance and inflammation, which can negatively affect metabolism. You can’t eliminate every stressor in life, but you can take charge of how you manage it. Setting boundaries and building in stress-relievers, like yoga, deep breathing, or even meditation, can make a big difference in keeping your mind and body balanced.  

Sleep hygiene 

“Poor sleep can disrupt appetite hormones like ghrelin and leptin, making weight loss harder,” says Butner. “Mind-body practices and consistent sleep routines can help,” she explained. Getting the recommended seven to nine hours of sleep per night and managing stress is also important for metabolic health. Studies show that both short (less than seven hours per day) and long (more than nine hours per day) sleep durations increase the risk of metabolic syndrome. Short sleep duration is also linked with an increased risk of obesity. 

ARE NATURAL AND OTC ALTERNATIVES AS EFFECTIVE AS OZEMPIC?

Natural alternatives to Ozempic can help support weight loss and metabolic health, but they’re not as effective as prescription weight loss drugs like Ozempic. Typically, they produce less-dramatic effects on weight and health markers like blood sugar levels as compared to prescription medication. But that doesn’t mean they’re not worth considering.

“These approaches tend to work more gradually, but they’re generally less likely to cause many of the negative side effects sometimes seen with prescription options, and they often support overall health in a more comprehensive way,” explains Butner. 

In fact, combining multiple approaches—supplements, exercise, diet tweaks, stress management, healthy sleep habits— may be your best bet for achieving safe and lasting results. Together, they can promote significant improvements in body composition, blood sugar levels, and overall health. ”When combined with sustainable diet, exercise, and lifestyle habits, natural strategies can be highly effective for long-term weight management,” says Butner.

HOW TO CHOOSE THE RIGHT OZEMPIC ALTERNATIVE FOR YOU

It’s always best to choose an approach that aligns with your health needs, safety concerns, individual preferences, and long-term wellness goals. Before choosing an Ozempic alternative, it’s best to evaluate factors like:

• Your personal goals

• Your budget

• Your health status, including any underlying health conditions

If you have a modest amount of weight to lose and you’ve had success with lifestyle and dietary changes in the past, natural Ozempic alternatives might be a suitable option. Just remember that it’s best to combine them with lifestyle changes like following a healthy diet and increasing physical activity levels. 

Prescription options, like Ozempic or another medication, may be more appropriate if you have a significant amount of weight to lose, have an underlying health condition, or you’ve previously found diet and exercise changes ineffective.  

POTENTIAL RISKS AND PRECAUTIONS WITH OZEMPIC ALTERNATIVES

Like prescription medications, Ozempic alternatives including supplements can trigger side effects in some people. 

For example, supplementing with CLA can lead to side effects like gas and diarrhea, while garcinia cambogia supplements may cause liver damage in extreme cases. It’s also possible for certain herbal supplements to interact with common medications. 

This is why it’s important to discuss any supplement changes with your healthcare provider. It’s also always a good idea to purchase third-party tested supplements from trusted brands and follow safe dosing recommendations. 

WHEN TO CONSULT A HEALTHCARE PROVIDER

Whether you’re beginning a new diet, trying a supplement for the first time, or considering a prescription weight-loss medication, it’s crucial to consult your healthcare provider, especially if you have existing health conditions or take other medications.

Your healthcare provider can help recommend Ozempic alternatives that won’t interact with your current medications and supplements, and align with your individual health needs. They can also answer any questions that you have and help you form a more personalized plan for weight management and improving metabolic health.

KEY TAKEAWAYS

• Ozempic is a prescription medication that’s effective for type 2 diabetes and often prescribed off-label for  weight management, but high costs, limited insurance coverage, side effects, and supply shortages have left many seeking alternatives.

• Natural Ozempic alternatives, such as Veracity’s Metabolism Ignite, green coffee bean extract, berberine, fiber supplements, and CLA, are not 1-1 substitutes for GLP-1 medications, but they can help support a healthy metabolism and promote weight loss.

• Lifestyle strategies—a nutrient-dense diet, regular exercise, managing stress, and adequate sleep, are essential for maintaining metabolic health and sustainable weight management.

• Combining supplements with dietary and lifestyle changes is usually more effective than relying on a single approach.

• Always consult a healthcare provider before starting new supplements.

FREQUENTLY ASKED QUESTIONS (FAQS)

What works like Ozempic, but is cheaper?

Some prescription alternatives, like Trulicity, are slightly less expensive than Ozempic. There are also supplements (including Veracity’s Metabolism Ignite), that can support metabolic health and weight management at a much lower cost.

What to do if you can’t afford Ozempic?

If you can’t afford Ozempic, it’s best to consult your healthcare provider. They can recommend suitable options based on your health background and preferences, which may include diet, lifestyle changes, and/or supplements. 

What is a relatively new drug that may potentially be more effective than Ozempic?

Zepbound (Tirzepatide) is a GLP-1 and GIP receptor agonist that is FDA-approved for weight loss and may provide improved weight loss outcomes than Ozempic, though it can be more expensive.

What is the closest over-the-counter to Ozempic?

There isn’t an over-the-counter product that works quite like Ozempic and other prescription weight loss medications. But there are some natural alternatives to help support appetite control, blood sugar, and metabolism. These include berberine, green coffee bean extract, and fiber supplements, and Veracity’s Metabolism Ignite.

What can be used as a substitute for Ozempic?

Depending on your health and goals, substitutes for Ozempic may include prescription medications, like Saxenda, Zepbound, or Trulicity, or a combination of natural supplements and diet and lifestyle modification. 

*At time of publishing, September 2025; price may vary.