Injection Site Irritation
As many fertility drugs are injectables, Dr. Guanche says injection site issues make up the majority of the fertility medication side effects. While redness and bruising are the most common issues, she has also seen these injectable drugs cause occasional blood blisters. Cut down on these temporary flare-ups by making sure you are following the proper injection procedure. (Many fertility doctors provide educational videos and lessons to help with training.)
While the most common skin problems are caused by the daily shots, some women can also have an adverse reaction to the drug solution that contains the fertility medication. Dr. Lauren Bishop says one example is progesterone. “These injections are made with oil, and some women can have a sensitivity reaction to the sesame oil,” she says. “Women who experience redness and itching can try switching to a different base such as olive oil, which is less likely to cause local skin irritation.”
Dr. Lucky Sekhon says skin redness can occur from elevated estrogen levels, which can cause dilation of blood capillaries and flushing of the skin. “Redness and flushing may accompany the hot flashes, which can sometimes be experienced with medications such as Clomid or letrozole,” she explains.
“I recommend patients wear light cotton clothing and layers so that they can adjust their body temperature and minimize discomfort,” Dr. Sekhon says. “Flushing of the skin usually accompanies hot flashes. Hot flashes themselves can be reduced or prevented with medical treatments such as hormone replacement therapy and certain antidepressants and seizure medications.”
Additional Side Effects
It’s hard to predict which, if any, side effects you may experience as skin changes caused by hormonal fertility drugs can be varied. But in addition to injection site irritation and acne, Dr. Green says patients may also face: “dryness of the skin, hair loss, under eye bags and pigmentation, discoloration of the face and melasma, redness and rosacea flares.” The good news, according to Dr. Guanche, is that if you do experience skin reactions to fertility treatments, most will subside once the fertility treatment has passed.
Once a fertility treatment or pregnancy has ended and skincare restrictions are no longer needed, Dr. Green treats patients’ lingering acne with chemical peels, bleaching creams with hydroquinones, and Cosmelan peels to help combat melasma. “Chemical peels can help increase skin cell turnover and treat the facial discoloration,” she says. Products like vitamin C serum (a powerful antioxidant for the skin) and retinols (an ingredient that is not safe for use during pregnancy) can also be effective at treating skin discoloration from the hormonal after-effects.
When to Be Concerned
According to Dr. Pierre, the majority of these skin-related issues are completely normal and should resolve once the hormonal treatments stop. “They can, however, persist throughout the subsequent pregnancy and into the postpartum period,” he says. Typically, there is no need to be alarmed if you do find your skin acting up.
“The side effects we worry about are skin infections, which would show signs of swelling, redness, pus production, fevers, and chills,” says Dr. Daniel Skora. These, he says, need to be addressed by a physician and likely will need antibiotics. Skora advises that before beginning fertility treatments, patients, especially those with sensitive skin, should speak with their dermatologist or physician about possible side effects.
Klein admittedly wasn’t thrilled to go through all of the skin changes that her fertility treatments brought on, but she says she would absolutely do it all over again. “In the scheme of all the side effects – weight gain, sleeplessness, nightmares, bruising – skin breakouts are a minor nuisance in the quest to have a baby.” Plus, there is one skin upside you can always count on: the famous glow.